Why the study?
Does Roux-en-Y gastric bypass surgery reprogram defended body weight in diet-induced obese mice?
Population
Male C57BL6J mice reaching different degrees of obesity on a high-fat diet either with ad libitum access or…
Comparison
Roux-en-Y gastric bypass surgery (RYGB) vs Chow controls
Design
Preclinical
Authors
Loading...
Supports RYGB reprogramming defended body weight in obese mice; hypothesis-generating for humans, requires clinical validation before practice change.
Does Roux-en-Y gastric bypass surgery reprogram defended body weight in diet-induced obese mice?
RYGB appears to reprogram a new defended body weight by selectively abolishing the defense of a higher fat mass level while maintaining the defense of lean mass.
Zheng et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: