Why the study?
Does the measles virus matrix protein selectively disappear from the central nervous system during the progression of experimental SSPE in hamsters?
Population
Hamsters with an experimental model of subacute sclerosing panencephalitis induced by intracerebral…
Design
Preclinical
Follow-up
17 days after inoculation
Authors
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Matrix protein loss may underlie defective measles persistence in SSPE models; leaves open relevance to human CNS infection.
Does the measles virus matrix protein selectively disappear from the central nervous system during the progression of experimental SSPE in hamsters?
The selective disappearance of the measles virus matrix protein in the hamster brain model provides a mechanistic explanation for the defective nature of the virus in subacute sclerosing panencephalitis.
Johnson et al. (1981) studied this question.
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