March 1, 2003British Journal of PharmacologyOpen Access

Inhibition of G protein‐activated inwardly rectifying K+ channels by fluoxetine (Prozac)

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Population

Xenopus oocytes expressing GIRK1/GIRK2, GIRK2, or GIRK1/GIRK4 subunits, and cloned Xenopus A adenosine…

Design

Preclinical

Authors

TKToru KobayashiKindai University KWKazuo WashiyamaTokyo Rinkai Hospital KIKazutaka IkedaTokyo Metropolitan Institute of Medical Science

Discussion

Member takes

Implication

May explain fluoxetine's cardiac effects via GIRK; animal data leaves open human relevance.

Structured PICO

Population

Xenopus oocytes expressing GIRK1/GIRK2, GIRK2, or GIRK1/GIRK4 subunits, and cloned Xenopus A(1) adenosine receptor

Intervention

Fluoxetine

Outcome

Inhibition of inward currents through basal GIRK activitysurrogate

Fluoxetine inhibits G protein-activated inwardly rectifying K+ channels (GIRK) at low micromolar concentrations, which may explain some of its therapeutic and adverse effects.

Cite This Study

Kobayashi et al. (2003) studied this question.

synapsesocial.com/papers/6a7285aca7fbea1e4408afcb https://doi.org/10.1038/sj.bjp.0705172

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Inhibition of G protein‐activated inwardly rectifying K+ channels by fluoxetine (Prozac)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of G protein‐activated inwardly rectifying K+ channels by fluoxetine (Prozac)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider