Key result
Fluoxetine caused a use- and dose-dependent blockade of the neuronal voltage-dependent potassium channel Kv1.1, slowing both activation and deactivation kinetics.
Population
Xenopus laevis oocytes expressing a neuronal, voltage-dependent potassium (K+) channel (RCK1; Kv1.1)
Design
Preclinical
Authors
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Should not change fluoxetine prescribing; leaves open whether Kv1.1 blockade contributes to clinical adverse effects.
Fluoxetine blocks the neuronal voltage-dependent potassium channel Kv1.1 in a use- and dose-dependent manner, providing a biophysical model that may help explain clinical symptoms seen with elevated serum concentrations.
Tytgat et al. (1997) studied this question. Fluoxetine was evaluated on Blockade of K+ currents and channel kinetics. Fluoxetine caused a use- and dose-dependent blockade of the neuronal voltage-dependent potassium channel Kv1.1, slowing both activation and deactivation kinetics.
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