June 2, 2004Journal of Cardiovascular Pharmacology
Attenuated Inhibition of L-type Calcium Currents by Troglitazone in Fructose–Fed Rat Cardiac Ventricular Myocytes
Why the study?
Does troglitazone inhibit L-type calcium currents differently in ventricular myocytes from fructose-fed rats compared to control rats?
Population
Ventricular myocytes isolated from rats on 12 to 16 weeks of fructose-enriched feeding and age-matched…
Comparison
Troglitazone vs Age-matched control rat myocytes
Design
Preclinical
Authors
Discussion
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Implication
Attenuated troglitazone inhibition of ICa,L in hyperinsulinemic model; hypothesis-generating and should not yet change practice.
Structured PICO
Does troglitazone inhibit L-type calcium currents differently in ventricular myocytes from fructose-fed rats compared to control rats?
P
Population
Ventricular myocytes isolated from rats on 12 to 16 weeks of fructose-enriched feeding (hyperinsulinemia model) and age-matched control rats
I
Intervention
Troglitazone
C
Comparator
Age-matched control rat myocytes
O
Outcome
Inhibition of L-type Ca current (ICa,L) measured by whole-cell voltage-clamp techniquessurrogate
The inhibitory effect of troglitazone on cardiac L-type calcium currents is attenuated in a rat model of hyperinsulinemia compared to controls.
Cite This Study
Arikawa et al. (2004) studied this question.