Population
Synthetic thick filaments (myosin)
Comparison
Cross-linking with dimethyl suberimidate at… vs Different pH values within the tested range
Design
Preclinical
Authors
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Alkaline pH may reposition myosin heads in animal thick filaments; leaves open relevance to human cardiac contractility or pH-related dysfunction.
The study demonstrates that myosin heads move away from the thick filament surface at alkaline pH but remain close at neutral pH.
Sutoh et al. (1978) studied this question.
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