April 13, 2005Developmental Dynamics

Dynamic balance between activation and repression regulates pre‐mRNA alternative splicing during heart development

View Full Paper

Ask AI

Bookmark

Population

Mouse and chicken embryonic and adult hearts, and cardiomyocytes

Design

Preclinical

Authors

ALAndrea N. LaddCleveland Clinic Lerner College of Medicine MSMyrna G. StenbergUniversity of North Carolina at Chapel Hill MSMaurice S. SwansonUniversity of Florida

Discussion

Member takes

Implication

Hypothesis-generating for cTNT splicing in development; leaves open relevance to human cardiomyopathy or therapeutic targeting.

Structured PICO

Population

Mouse and chicken embryonic and adult hearts, and cardiomyocytes

Intervention

Dominant-negative proteins targeting CELF and PTB activities

Outcome

Regulation of cardiac troponin T (cTNT) exon 5 alternative splicingsurrogate

Alternative splicing of cardiac troponin T during heart development is determined by a dynamic balance between positive (CELF) and negative (PTB, MBNL) regulatory proteins.

Cite This Study

Ladd et al. (2005) studied this question.

synapsesocial.com/papers/6a728dcbac440176ef2abbb7 https://doi.org/10.1002/dvdy.20382

View Full Paper

Ask AI

Bookmark