Population
Primary skeletal muscle cultures and nonmuscle cell lines
Comparison
Identification and mutation of intron elements vs Nonmuscle cells or unmutated elements
Design
Preclinical
Authors
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Does not alter clinical management of cardiac conditions; extends mechanistic understanding of cTnT splicing in animal models.
The study identifies four muscle-specific splicing enhancers that regulate the developmental alternative splicing of the cardiac troponin T gene.
Ryan et al. (1996) studied this question.
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