Key result
Structured diagnostic algorithm clarifies evaluation of acquired and hereditary warfarin resistance.
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Some patients need higher-than-expected doses of warfarin (Coumadin) to get their international normalized ratio (INR) into the therapeutic range. The cause of warfarin resistance can be either acquired (eg, poor compliance, drug interactions, dietary interactions) or hereditary, but the genetic mechanisms of warfarin resistance are not well understood. This review offers an algorithm for the evaluation of patients with suspected warfarin resistance.
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Osinbowale et al. (2009) conducted a review in Warfarin resistance. Evaluation algorithm for warfarin resistance was evaluated. Warfarin resistance may result from acquired factors or poorly understood hereditary mechanisms, and can be systematically evaluated using a proposed diagnostic algorithm.
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