Why the study?
Does low-molecular-weight heparin compared to aspirin reduce thromboembolic events, major haemorrhage, and death in patients after total hip replacement?
Population
108,584 patients who underwent total hip replacement between April 2003 and September 2008 in England and…
Comparison
Low-molecular-weight heparin (LMWH) vs Aspirin
Design
Cohort
Follow-up
90 days
Authors
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Should not alter aspirin use for post-hip replacement prophylaxis; hypothesis-generating for RCTs to confirm mortality benefit.
Does low-molecular-weight heparin compared to aspirin reduce thromboembolic events, major haemorrhage, and death in patients after total hip replacement?
LMWH is associated with a lower 90-day mortality compared to aspirin after total hip replacement when adjusted for baseline risk factors using propensity score matching.
Jameson et al. (2011) studied this question.
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