Why the study?
Do vitamin D receptor activators prevent left ventricular hypertrophy and myocardial fibrosis in a rat model of chronic renal failure?
Population
Male Wistar rats with chronic renal failure (CRF) induced by 7/8 nephrectomy
Comparison
Vitamin D receptor activators including… vs Placebo group and a Sham group with normal renal…
Design
Preclinical
Follow-up
4 weeks
Authors
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Paricalcitol's unique antifibrotic profile in this rat model warrants targeted human studies; does not yet support preferential use in clinical practice.
Do vitamin D receptor activators prevent left ventricular hypertrophy and myocardial fibrosis in a rat model of chronic renal failure?
In a rat model of chronic renal failure, all tested VDRAs prevented left ventricular hypertrophy, but only paricalcitol significantly reduced myocardial fibrosis.
Panizo et al. (2013) studied this question.
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