Why the study?
Does calcitriol ameliorate cardiac remodelling in subtotally nephrectomized rats?
Population
Three-month-old male Sprague-Dawley rats subjected to subtotal nephrectomy (SNX) or sham operation
Comparison
Calcitriol starting immediately after operation vs Vehicle
Design
Preclinical, Randomized to subtotal nephrectomy (SNX) or sham operation
Follow-up
12 weeks
Authors
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Hypothesis-generating for calcitriol in uremic cardiac remodelling; human trials needed before any clinical consideration.
Does calcitriol ameliorate cardiac remodelling in subtotally nephrectomized rats?
Non-hypercalcaemic doses of calcitriol ameliorated cardiac remodelling, including capillary deficit and fibrosis, in a rat model of chronic renal failure.
Koleganova et al. (2008) studied this question.
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