RT-PCR demonstrating SYT/SSX-2 fusion transcripts can confirm the diagnosis of primary synovial sarcoma of the lung.
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Supports molecular diagnosis of rare primary pulmonary synovial sarcoma; leaves open prospective validation before routine clinical adoption.
A 45 -year-old woman presented chest pain and a well-defined oval shaped mass on a chest radiograph. A malignant pulmonary tumor was suspected and a right pneumonectomy was performed. The tumor measured about 13 x 12 cm, was pale-yellow in color and soft in texture. Histologically, it had round to oval and spindle-shaped cells with minimal cytoplasm, hyperchromatic nuclei, inconspicuous mitoses and only slight fibrous stroma. Immunohistochemically, the tumor cells were positive for vimentin, CD 99, BCL-2 protein and EMA. The reverse transcriptase-polymerase chain reaction (RT-PCR), using RNA extracted from fresh-frozen tissue, demonstrated SYT/SSX-2 fusion transcripts, confirming the diagnosis of synovial sarcoma.
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Zamarrón et al. (2006) studied this question.
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