Why the study?
Does quinidine administration precipitate digitalis toxicity in patients on prolonged digitalis therapy?
Does quinidine administration precipitate digitalis toxicity in patients on prolonged digitalis therapy?
This case highlights the risk of precipitating digitalis toxicity when quinidine is administered to patients on prolonged digitalis therapy.
May warrant caution with quinidine in digoxin-treated patients; leaves open need for prospective confirmation of this interaction.
In a 90-year-old man undergoing prolonged digitalis therapy, digitalis toxicity was precipitated by the administration of quinidine. The electrocardiogram revealed supraventricular bidirectional tachycardia, a rare but characteristic arrhythmia associated with digitalis toxicity. Upon withdrawal of digoxin, the clinical and ECG signs disappeared. A diagnosis of digitalis toxicity rather than quinidine intolerance led to appropriate treatment.
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Manyari et al. (1981) studied this question.
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