Why the study?
Does increasing and decreasing hydrostatic pressures modulate the contraction of in vitro beating mouse cardiac syncytia?
Does increasing and decreasing hydrostatic pressures modulate the contraction of in vitro beating mouse cardiac syncytia?
This in vitro study successfully verified the Frank-Starling law in mouse cardiac syncytia using a hydrostatic pressure bioreactor and image processing analysis.
Supports in vitro cardiac models for pressure-response studies; leaves open translation to human physiology.
We have studied beating mouse cardiac syncytia in vitro in order to assess the inotropic, ergotropic, and chronotropic effects of both increasing and decreasing hydrostatic pressures. In particular, we have performed an image processing analysis to evaluate the kinematics and the dynamics of those pressure-loaded beating syncytia starting from the video registration of their contraction movement. By this analysis, we have verified the Frank-Starling law of the heart in in vitro beating cardiac syncytia and we have obtained their geometrical-functional classification.
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Fassina et al. (2015) studied this question.
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