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should be possible to gather enough data from patients not receiving prophylaxis with penicillin to make the study worth while.Our policy is to counsel patients (or their parents) on the risks of infection; to give them a card containing information on what to do in case of suspected sepsis; to attempt to follow them up annually; and to provide a course of antibiotics (amoxycillin) for them to keep at home for use at the earliest sign of infection.
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Muller et al. (1994) studied this question.
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