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October 1, 2007Journal of Cardiovascular Pharmacology

Adverse Balance of Nitric Oxide/Peroxynitrite in the Dysfunctional Endothelium Can be Reversed by Statins

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Why the study?

Do statins improve the [NO]/[ONOO-] balance in dysfunctional endothelial cells?

Population

Normal and dysfunctional human umbilical vein endothelial cells

Comparison

Atorvastatin or simvastatin for 24 hours vs Untreated cells or cells treated with…

Design

Preclinical

Follow-up

24 hours

Authors

GHGehan H. HeebaMinia UniversityMHMagdy K. HassanHalliburton (United Kingdom)MKMohamed Mansour KhalifaCairo University

Discussion

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Overview

Statins may improve endothelial NO balance in animal models; hypothesis-generating and should not yet change practice.

Structured PICO

Do statins improve the [NO]/[ONOO-] balance in dysfunctional endothelial cells?

P
Population
Normal and dysfunctional human umbilical vein endothelial cells (HUVEC) (dysfunction induced by 50 microg/mL oxidized-LDL)
I
Intervention
Atorvastatin or simvastatin for 24 hours
C
Comparator
Untreated cells (control) or cells treated with oxidized-LDL alone
O
Outcome
[NO]/[ONOO-] balance measured by electrochemical nanosensorssurrogate

Statins can restore endothelial function in vitro by reversing eNOS uncoupling and improving the nitric oxide to peroxynitrite balance.

Cite This Study

Heeba et al. (2007) studied this question.

synapsesocial.com/papers/6a729e163ce530166bc359fahttps://doi.org/10.1097/fjc.0b013e31811f3fd0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidized Low-density Lipoprotein Decreases the Expression of Endothelial Nitric Oxide Synthase1995 · 543 citations
  2. 2Endothelium-Dependent Effects of Statins2003 · 417 citations
  3. 3Atorvastatin Upregulates Type III Nitric Oxide Synthase in Thrombocytes, Decreases Platelet Activation, and Protects From Cerebral Ischemia in Normocholesterolemic Mice2000 · 391 citations
  4. 4Simvastatin, an HMG–Coenzyme A Reductase Inhibitor, Improves Endothelial Function Within 1 Month1997 · 958 citations
  5. 5Therapeutic Interventions in Endothelial Dysfunction: Endothelium as a Target Organ1997 · 27 citations