Subcutaneous inoculation of attenuated VEE virus in mice leads to survival with minimal brain involvement, unlike unattenuated virus or intracerebral inoculation.
No immediate clinical implications for VEE; leaves open optimized attenuation routes in future animal vaccine models.
Summary The pathogenesis of an attenuated and an unattenuated strain of Venezuelan equine encephalomyelitis (VEE) virus was studied in young adult mice by means of infectivity titrations and fluorescent antibody staining. Tissue infectivity and viral lethality were generally similar in mice inoculated intracerebrally (i.c.) or subcutaneously (s.c.) with unattenuated virus and i.c. with attenuated virus. The tissues most involved were brain, salivary glands, inguinal nodes and spleen. Mice inoculated s.c. with attenuated VEE virus survived the infection. Little virus was found in the brain.
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W. D. Kundin (1966) studied this question.
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