Key result
Inoculation with known subtypes of Venezuelan equine encephalomyelitis virus, with the exception of the attenuated TC-83 strain, was highly pathogenic for suckling mice.
Population
Mice (suckling, older, adult), guinea pigs, and duck embryo cell cultures
Comparison
Inoculation with known subtypes of Venezuelan… vs Comparison between different VEE virus strains
Design
Preclinical
Authors
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Differentiates VEE subtypes in suckling mice; leaves open validation of adult models for epizootic diagnostics.
Assessing virulence in adult mice or guinea pigs provides a rapid method for separating epizootic subtype IB from the attenuated TC-83 VEE virus isolate.
Calisher et al. (1974) studied Venezuelan equine encephalomyelitis (VEE) virus infection. Venezuelan equine encephalomyelitis (VEE) virus subtypes vs. Attenuated (TC-83) strain of VEE was evaluated on Pathogenicity and virulence. Inoculation with known subtypes of Venezuelan equine encephalomyelitis virus, with the exception of the attenuated TC-83 strain, was highly pathogenic for suckling mice.
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