Key result
VEE virus infection in mice reveals host-maturation events that shape strain-specific responses and survival.
Why the study?
The multifactorial interactions between different strains of Venezuelan Equine Encephalomyelitis virus and host responses in mice were not fully characterized.
Population
Mice of different ages infected with 23 strains of VEE virus
Comparison
Virus strains and host responses by age and infection route
Design
Experimental infection study
Authors
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Urges caution extrapolating murine VEE data to humans; leaves open whether maturation events shape clinical outcomes or vaccine responses.
Walder et al. (1979) studied Venezuelan Equine Encephalomyelitis Virus infection. 23 different strains of VEE virus was evaluated on Efficiency of infection, outcome of infection (lethality or protection), and survival time. Infection of mice with 23 different strains of VEE virus showed several host-maturation events that combine to provide a multifactorial specification of virus-strains and host-responses.
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