Key result
Experimental VEE virus infection in cotton and spiny rats produced peak titers on day 2 and viremia for 4 to 5 days, with neutralizing antibodies persisting for at least 9 months.
Experimental infection of spiny and cotton rats with VEE virus demonstrates their potential as reservoirs, characterized by high early viral titers and long-lasting neutralizing antibody responses.
Highlights candidate rodent reservoirs for VEE; leaves open field confirmation and spillover implications.
Ten spiny rats (Proechimys semispinosus) and 12 cotton rats (Sigmodon hispidus) were experimentally infected with VEE virus. Both are species that have been implicated as reservoirs of the virus in Panamá. VEE-virus titers were highest in the serum and throat on the 2nd day after inoculation. The values for Sigmodon were higher than for Proechimys. The duration of viremia, usually 4 to 5 days, was similar for the two species, but virus persisted in the throat of Sigmodon longer than in the serum and was present up to 7 days. Neutralizing antibody appeared 3 to 5 days after inoculation and preceded the disappearance of circulating virus by one or more days. Antibody titers reached a maximum by about 18 days and remained at high levels for at least 9 months.
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Young et al. (1969) studied Venezuelan Equine Encephalomyelitis (VEE) virus infection (n=22). Experimental VEE virus inoculation vs. Between species (Sigmodon vs Proechimys) was evaluated on VEE-virus titers and duration of viremia. Experimental VEE virus infection in cotton and spiny rats produced peak titers on day 2 and viremia for 4 to 5 days, with neutralizing antibodies persisting for at least 9 months.
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