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March 1, 1996Journal of NeuroscienceOpen Access

Tyrosine phosphorylation of the Kv1.3 potassium channel

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Population

Human embryonic kidney (HEK) 293 cells transiently expressing the Kv1.3 voltage-dependent potassium channel

Comparison

Coexpression of constitutively active tyrosine… vs Untreated cells or cells expressing a mutated…

Design

Preclinical

Authors

THTodd C. HolmesUniversity of California, IrvineDFDA FadoolBrandeis UniversityILI. B. LevitanUniversity of Pennsylvania

Discussion

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Implication

Y449 phosphorylation may suppress Kv1.3 current in neurons; leaves open its physiological role and therapeutic relevance in vivo.

Structured PICO

P
Population
Human embryonic kidney (HEK) 293 cells transiently expressing the Kv1.3 voltage-dependent potassium channel
I
Intervention
Coexpression of constitutively active tyrosine kinase v-src or human epidermal growth factor receptor; treatment with the specific membrane-permeant tyrosine phosphatase inhibitor pervanadate
C
Comparator
Untreated cells or cells expressing a mutated Kv1.3 channel (tyrosine 449 mutated to phenylalanine)
O
Outcome
Tyrosine phosphorylation of the Kv1.3 channel protein and Kv1.3 currentsurrogate

Tyrosine phosphorylation of the Kv1.3 potassium channel at position 449 by endogenous kinases suppresses channel current, demonstrating a constitutive phosphorylation/dephosphorylation cycle that regulates channel activity.

Cite This Study

Holmes et al. (1996) studied this question.

synapsesocial.com/papers/6a729f3bfebe604dd70ab1b3https://doi.org/10.1523/jneurosci.16-05-01581.1996
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In vivo and in vitro phosphorylation of the T lymphocyte type n (Kv1.3) potassium channel.1993 · 48 citations
  2. 2Properties of Kv2.1 K+ channels expressed in transfected mammalian cells.1994 · 128 citations
  3. 3Modulation of a voltage-activated potassium channel by peptide growth factor receptors1994 · 46 citations
  4. 4A voltage‐gated potassium channel in human T lymphocytes.1985 · 407 citations
  5. 5Phosphorylation and assembly of nicotinic acetylcholine receptor subunits in cultured chick muscle cells.1987 · 49 citations