Key result
Epidermal growth factor receptor tyrosine kinase up-regulates the human K(IR) 2.3 channel via phosphorylation of the Y234 residue.
Population
HEK 293 cells stably expressing human K(IR) 2.3 gene
Design
Preclinical
Authors
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Hypothesis-generating for EGFR-Kir2.3 signaling in electrophysiology; leaves open human cardiac relevance.
EGF receptor tyrosine kinase up-regulates the human K(IR) 2.3 channel via phosphorylation of the Y234 residue, which may be involved in endogenous regulation of cellular electrical activity.
Zhang et al. (2011) studied KIR2.3 channel regulation. EGF receptor tyrosine kinase inhibitors (genistein, AG556) and EGF was evaluated on K(IR) 2.3 current and tyrosine phosphorylation. Epidermal growth factor receptor tyrosine kinase up-regulates the human K(IR) 2.3 channel via phosphorylation of the Y234 residue.
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