Population
Human atrial cells and HEK 293 cells stably expressing human KCND3 (hKv4.3 channels)
Design
Preclinical
Authors
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Caution against clinical translation; extends mechanistic understanding of EGFR/Src regulation of human atrial I(to).
EGFR and Src-family kinases modulate the human cardiac transient outward potassium current via specific tyrosine phosphorylation sites, highlighting a mechanism for regulating cardiac electrophysiology.
Zhang et al. (2011) studied this question.
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