Why the study?
Does long-term treatment with cutaneous nitroglycerin patches induce cross-tolerance to intravenous nitroglycerin in patients with coronary artery disease?
Population
20 patients with coronary artery disease undergoing diagnostic cardiac catheterization
Comparison
Cutaneous nitroglycerin patch prior to cardiac… vs No cutaneous nitroglycerin patch prior to…
Design
Cohort
Follow-up
During diagnostic cardiac catheterization
Authors
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Supports cross-tolerance to IV nitroglycerin after patch use in CAD; hypothesis-generating and should not yet change practice.
Does long-term treatment with cutaneous nitroglycerin patches induce cross-tolerance to intravenous nitroglycerin in patients with coronary artery disease?
Long-term use of cutaneous nitroglycerin patches induces tolerance to the effects of intravenous nitroglycerin on left ventricular systolic pressure and coronary artery dilation, but not on left ventricular end-diastolic pressure.
Naito et al. (1993) studied this question.
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