Why the study?
Does long-term isosorbide dinitrate administration cause cross-tolerance to the circulatory effects of sublingual nitroglycerin?
Population
n=6 subjects
Comparison
Sustained-action isosorbide dinitrate 120 mg/day… vs Baseline response to sublingual nitroglycerin…
Design
Cohort
Follow-up
6 to 8 weeks
Authors
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Long-term isosorbide dinitrate was associated with cross-tolerance to nitroglycerin; hypothesis-generating and should not yet change practice.
Does long-term isosorbide dinitrate administration cause cross-tolerance to the circulatory effects of sublingual nitroglycerin?
Long-term administration of isosorbide dinitrate attenuates the venodilatory response to sublingual nitroglycerin, demonstrating cross-tolerance.
Robert Zelis (1975) studied this question.
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