Key result
Long-term administration of isosorbide dinitrate significantly attenuated nitroglycerin-induced venodilation, with venous volume failing to increase (2.95 to 2.95 ml/100 ml, P>.5).
Why the study?
Does long-term isosorbide dinitrate administration cause cross-tolerance to the circulatory effects of nitroglycerin?
Population
6 subjects
Comparison
Sustained-action isosorbide dinitrate 120 mg/day… vs Baseline response to sublingual nitroglycerin…
Design
Cohort
Follow-up
6 to 8 weeks
Authors
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May limit nitroglycerin rescue efficacy during long-term isosorbide dinitrate use; leaves open outcome impact and arteriolar effects.
Does long-term isosorbide dinitrate administration cause cross-tolerance to the circulatory effects of nitroglycerin?
Absolute Event Rate: 2.95% vs 3.28%
Long-term administration of isosorbide dinitrate induces cross-tolerance to the venodilatory, but not arteriolar, effects of sublingual nitroglycerin.
R. Zelis (1975) studied this question. Isosorbide dinitrate vs. Baseline (prior to isosorbide dinitrate administration) was evaluated on Venous volume at 30 mm Hg (VV[30]) after sublingual nitroglycerin. Long-term administration of isosorbide dinitrate significantly attenuated nitroglycerin-induced venodilation, with venous volume failing to increase (2.95 to 2.95 ml/100 ml, P>.5).
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