Why the study?
Does acute oral administration of isosorbide dinitrate alter hemodynamic responses differently in patients with essential hypertension compared to normotensives?
Population
21 subjects (12 patients with sustained essential hypertension and 9 normotensives of the same age)
Comparison
Acute oral administration of 20 mg of isosorbide… vs Baseline measurements and normotensive control…
Design
Cohort
Follow-up
3 hours
Authors
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Differential BP lowering by hypertensive status may guide acute use; leaves open long-term outcome trials before practice change.
Does acute oral administration of isosorbide dinitrate alter hemodynamic responses differently in patients with essential hypertension compared to normotensives?
Isosorbide dinitrate increases aortic diameter and arterial distensibility in both normotensives and hypertensives, but significantly decreases mean arterial pressure only in hypertensives.
Pannier et al. (1990) studied this question.
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