July 1, 1983Journal of Cardiovascular Pharmacology
Action of Vasodilating Drugs on Small and Large Arteries of Hypertensive Patients
Why the study?
Do different vasodilating drugs have varying effects on blood pressure, arterial diameter, and blood flow in patients with sustained essential hypertension?
Population
Patients with sustained essential hypertension
Comparison
Administration of vasodilating drugs vs Baseline (before administration)
Design
Cohort
Authors
Discussion
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Implication
Divergent large-artery effects among vasodilators in hypertension; hypothesis-generating and should not yet change practice.
Structured PICO
Do different vasodilating drugs have varying effects on blood pressure, arterial diameter, and blood flow in patients with sustained essential hypertension?
P
Population
Patients with sustained essential hypertension
I
Intervention
Administration of vasodilating drugs (nitroglycerin, captopril, dihydralazine, diltiazem, and isosorbide dinitrate)
C
Comparator
Baseline (before administration)
O
Outcome
Blood pressure, arterial diameter, and blood flow of the brachial arterysurrogate
Antihypertensive drugs that dilate small arteries can have divergent effects on the caliber of large peripheral arteries and peripheral blood flow.
Cite This Study
Simon et al. (1983) studied this question.