January 1, 1985Journal of Cardiovascular Pharmacology
Vasodilatation of Small and Large Arteries in Hypertension
Key result
Vasodilating antihypertensive drugs have varying effects on the diameter and compliance of large arteries despite similar blood pressure reductions in patients with essential hypertension.
Why the study?
Do different vasodilating antihypertensive drugs have distinct effects on small and large arteries in patients with essential hypertension?
Population
Patients with essential hypertension
Design
Review
Authors
Discussion
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Implication
Vasodilators differentially affect large-artery diameter at similar BP reductions; hypothesis-generating and leaves open outcome relevance.
Structured PICO
Do different vasodilating antihypertensive drugs have distinct effects on small and large arteries in patients with essential hypertension?
P
Population
Patients with essential hypertension
E
Exposure
Vasodilating antihypertensive drugs (alpha- and beta-blocking drugs, dihydralazine, nitrates, renin-angiotensin inhibitors, and calcium-entry inhibitors)
O
Outcome
Changes in brachial artery diameter, blood flow, blood flow velocity, and arterial compliancesurrogate
Different classes of antihypertensive drugs have varying effects on large artery conducting and buffering functions independent of blood pressure lowering, which may influence cardiovascular prognosis.
Cite This Study
Levenson et al. (1985) conducted a review in Essential hypertension. Vasodilating antihypertensive drugs was evaluated. Vasodilating antihypertensive drugs have varying effects on the diameter and compliance of large arteries despite similar blood pressure reductions in patients with essential hypertension.