Why the study?
Does controlled-release isosorbide-5-mononitrate 60 mg once daily improve exercise capacity and reduce anginal symptoms in patients with stable exertional angina on chronic beta-blockade?
Does controlled-release isosorbide-5-mononitrate 60 mg once daily improve exercise capacity and reduce anginal symptoms in patients with stable exertional angina on chronic beta-blockade?
The addition of once-daily controlled-release isosorbide-5-mononitrate to beta-blockade significantly improves exercise capacity and reduces anginal symptoms in patients with stable angina.
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Supports adding controlled-release isosorbide-5-mononitrate to beta-blockade in stable angina; extends evidence for nitrate combination therapy on exercise tolerance.
Uusitalo et al. (1988) studied this question.
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