Why the study?
Does isosorbide-5-mononitrate 20 mg twice daily improve exercise performance and prevent tolerance or rebound angina in patients with stable angina pectoris?
Does isosorbide-5-mononitrate 20 mg twice daily improve exercise performance and prevent tolerance or rebound angina in patients with stable angina pectoris?
Isosorbide-5-mononitrate 20 mg given twice daily, 7 hours apart, improves exercise performance in stable angina without causing pharmacologic tolerance or rebound angina.
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Supports IS-5-MN 20 mg twice daily in stable angina; confirms sustained efficacy without tolerance or rebound.
Udho Thadani (1994) studied this question.
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