Why the study?
Does slow-release isosorbide-5-mononitrate reduce ST-segment depression in patients with coronary artery disease and stable angina pectoris?
Does slow-release isosorbide-5-mononitrate reduce ST-segment depression in patients with coronary artery disease and stable angina pectoris?
Slow-release isosorbide-5-mononitrate 60 mg once daily provides effective anti-ischemic activity by reducing ST-segment depression without significant tolerance after short- and long-term therapy.
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Supports once-daily slow-release isosorbide-5-mononitrate in stable angina; confirms sustained anti-ischemic efficacy without tolerance.
Mitrović et al. (1991) studied this question.
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