What does this research mean for the field?

Isosorbide-5-mononitrate exerts its antianginal effects primarily by reducing left ventricular preload, which diminishes myocardial oxygen requirements without altering cardiac index or systemic vascular resistance. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1985Rinsho yakuri/Japanese Journal of Clinical Pharmacology and TherapeuticsOpen Access

Hemodynamic effects of isosorbide-5-mononitrate (TY-10368) on exercise-induced angina pectoris.

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Why the study?

Does isosorbide-5-mononitrate improve hemodynamic parameters and reduce ST-segment depression during exercise in patients with effort angina pectoris?

Structured PICO

Does isosorbide-5-mononitrate improve hemodynamic parameters and reduce ST-segment depression during exercise in patients with effort angina pectoris?

Population

11 patients with effort angina pectoris (mean age 51, 10 male, 1 female, 3 with prior MI) who developed significant ischemic ST depression and chest pain during supine bicycle ergometer exercise.

Intervention

Isosorbide-5-mononitrate (ISMN) 20 mg oral single dose, evaluated 120 minutes after administration.

Comparator

Control exercise test performed before ISMN administration (self-controlled baseline).

Outcome

Hemodynamic and echocardiographic measurements (ST-segment depression, blood pressure, pulmonary capillary wedge pressure, left atrial volume, left ventricular end-diastolic volume) at rest and during angina-limited supine multi-stage bicycle ergometer exercise testings.surrogate

A single 20 mg oral dose of isosorbide-5-mononitrate significantly reduces exercise-induced ST depression and pulmonary capillary wedge pressure in patients with effort angina, primarily through preload reduction.

Limitations

Small sample size
Difficulty in accurately measuring coronary blood flow during exercise due to catheter movement

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Supports preload reduction with ISMN in effort angina; hypothesis-generating pending randomized outcome trials.

Cite This Study

Tsunekawa et al. (1985) studied this question.

synapsesocial.com/papers/6a148c68bf7bc75b74bd6b0f https://doi.org/10.3999/jscpt.16.427

Topics

Echocardiography

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Hemodynamic effects of isosorbide-5-mononitrate (TY-10368) on exercise-induced angina pectoris.

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

Hemodynamic effects of isosorbide-5-mononitrate (TY-10368) on exercise-induced angina pectoris.

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider