Evaluation of antianginal effects of isosorbide 5-mononitrate (TY-10368) with serial multistage treadmill exercise testing.

11 patients with stable effort angina pectoris (mean age 54.5 years, 10 male, 1 female). All patients had >75% organic stenosis in at least one major coronary artery, and 7 had a prior myocardial infarction.

Isosorbide 5-mononitrate 20 mg single oral dose

Single oral dose of placebo (administered 2 to 7 days prior to the test drug according to an identical test protocol)

Treadmill exercise duration at 2, 4, and 7 hours after administrationsurrogate