Why the study?
Does captopril combined with simvastatin improve clinical efficacy and renal function in patients with early diabetic nephropathy compared to either drug alone?
Does captopril combined with simvastatin improve clinical efficacy and renal function in patients with early diabetic nephropathy compared to either drug alone?
Combination therapy with captopril and simvastatin significantly improves renal function markers in early diabetic nephropathy compared to either drug alone.
Combination improves renal markers over monotherapy in early diabetic nephropathy; extends monotherapy evidence to dual regimens.
Objective To observe the clinical efficacy of captopril combined with simvastatin for treating patients with early diabetic nephropathy.Methods 180 patients with diabetic nephropathy were randomly divided into three groups,and each group had 60 cases,group A was given captopril for treatment,group B was given simvastatin and group C was received captopril and simvastatin for treatment.The clinical efficacy,renal function before and after treatment and incidence of adverse reactions were compared in three groups.Results The clinical efficacy of group C was significantly better than group A and group B ( P ＜ 0.05 ) ; after treatment,the value of Ma/Cr,SCR and Bun of three groups were lower than pre-treatment ( t =3.12,3.08,3.17,3.41,3.19,3.20,3.04,3.44,3.48,all P ＜ 0.05 ) ;and the value of Ma/Cr,SCR and Bun after treatment in group C were significantly lower than group A and group B ( t =4.58,4.69,5.02,4.89,5.11,4.87,all P ＜0.05 ) ;the incidence of adverse reactions in group C was significantly lower than the other two groups.Conclusion Captopril combined with simvastatin could significantly improve the clinical efficacy of the early diabetic nephropathy and had small side effects.
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Guizhen Yang (2012) studied this question.
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