Key result
Short-term captopril therapy (37.5 mg/day for 20 days) significantly increased microalbuminuria in early diabetic nephropathy (p<0.05) but decreased albuminuria in advanced disease (p<0.05).
Why the study?
Does captopril alter clinical and biochemical parameters in patients with diabetic nephropathy?
Observational (n=21)
Does captopril alter clinical and biochemical parameters in patients with diabetic nephropathy?
Short-term low-dose captopril therapy had divergent effects on renal parameters depending on the stage of diabetic nephropathy, increasing microalbuminuria in early stages while decreasing albuminuria and GFR in advanced stages.
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Stage-specific captopril effects on albuminuria require caution in early diabetic nephropathy; hypothesis-generating for differential ACEI responses by disease stage.
Gültekin et al. (1993) conducted an observational in Diabetic nephropathy (n=21). Captopril was evaluated on Clinical and biochemical parameters. Short-term captopril therapy (37.5 mg/day for 20 days) significantly increased microalbuminuria in early diabetic nephropathy (p<0.05) but decreased albuminuria in advanced disease (p<0.05).
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