Key result
Captopril cuts exercise-induced microalbuminuria ~67% vs placebo in normotensive diabetics without altering blood pressure.
Why the study?
The effect of captopril on exercise-induced microalbuminuria in normotensive diabetic patients with early stage nephropathy was unclear.
Does captopril reduce exercise-induced microalbuminuria in normotensive diabetic patients with early-stage nephropathy?
Comparison
Captopril (two 25 mg doses in 24 hours) vs placebo prior to exercise test
Design
Randomised double blind crossover trial
Follow-up
24 hours
Authors
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Supports early captopril use in normotensive diabetics with exercise-induced microalbuminuria; extends ACE inhibitor renoprotection independent of blood pressure effects.
RCT (n=64)
Double blind
Randomised
No
Does captopril reduce exercise-induced microalbuminuria in normotensive diabetic patients with early-stage nephropathy?
Absolute Event Rate: 78% vs 239%
p-value: p=<0.001
Short-term captopril administration significantly reduces exercise-induced microalbuminuria in normotensive diabetic patients with early nephropathy without altering systemic blood pressure.
Romanelli et al. (1989) conducted an RCT in Normotensive diabetes with early stage nephropathy (n=64). Captopril vs. Placebo was evaluated on Urinary albumin excretion rate one hour after exercise in diabetic patients (p=<0.001). Captopril significantly reduced exercise-induced microalbuminuria in normotensive diabetic patients compared to placebo (78 µg/min vs 239 µg/min, p<0.001) without affecting systemic blood pressure.
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