Why the study?
Does complete stoppage of coronary blood flow produce transmural metabolite gradients in the left ventricle of open-chest dogs?
Population
Open-chest dogs
Comparison
Complete stoppage of right and left coronary… vs Normally perfused ventricle (control studies)
Design
Preclinical
Follow-up
15 or 30 seconds
Authors
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Suggests subendocardial ischemia vulnerability arises from higher energy demand; leaves open whether transmural gradients occur in humans.
Does complete stoppage of coronary blood flow produce transmural metabolite gradients in the left ventricle of open-chest dogs?
The contracting ventricle uses energy unevenly, suggesting that greater subendocardial vulnerability in myocardial ischemia is partly due to a greater energy need in this region.
Dunn et al. (1975) studied this question.
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