Why the study?
Does candesartan improve stroke survival and reduce brain oxidative stress compared to amlodipine in salt-loaded stroke-prone spontaneously hypertensive rats?
Population
Salt-loaded stroke-prone spontaneously hypertensive rats (SHRSP) (n=61 for stroke survival experiment)
Comparison
Candesartan or angiotensin II infusion vs Amlodipine (1 mg/kg per day orally) or control
Design
Preclinical
Authors
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Does not support preferring candesartan over amlodipine for stroke prevention; leaves open translation from this rat model to clinical practice.
Does candesartan improve stroke survival and reduce brain oxidative stress compared to amlodipine in salt-loaded stroke-prone spontaneously hypertensive rats?
In a rat model of salt-exacerbated stroke, AT1 receptor blockade with candesartan improved survival and reduced brain oxidative stress more effectively than calcium channel blockade with amlodipine, despite comparable blood pressure lowering.
Kim‐Mitsuyama et al. (2005) studied this question.
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