Why the study?
Does imidapril prevent stroke in stroke-prone spontaneously hypertensive rats?
Population
Salt-loaded stroke-prone spontaneously hypertensive rats
Comparison
Imidapril administered orally vs Enalapril, hydralazine, and a control group
Design
Preclinical
Follow-up
Up to 12 weeks
Authors
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Hypothesis-generating in hypertensive rat models; does not support clinical use pending human trials.
Does imidapril prevent stroke in stroke-prone spontaneously hypertensive rats?
Imidapril prevents stroke in stroke-prone spontaneously hypertensive rats at doses of 0.5 mg/kg/day or more, likely through amelioration of kidney dysfunction rather than blood pressure reduction.
Ogiku et al. (1993) studied this question.
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