Why the study?
Does optimized glycemic control by insulin therapy decrease the proportion of atherogenic small dense LDL particles in diabetic patients?
Population
37 IDDM patients and 33 NIDDM patients in poor glycemic control, along with two respective age-, sex-, and…
Comparison
Optimized glycemic control via insulin therapy… vs Baseline and matched nondiabetic control groups.
Design
Cohort
Follow-up
3 months
Authors
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Glycemic optimization may reduce atherogenic LDL in NIDDM; supports mechanistic hypothesis but leaves open outcome impact pending RCTs.
Does optimized glycemic control by insulin therapy decrease the proportion of atherogenic small dense LDL particles in diabetic patients?
Improving glycemic control with insulin in type 2 diabetes reduces the proportion of atherogenic small dense LDL particles, providing a mechanistic explanation for the cardiovascular benefits of strict glycemic management.
Caixàs et al. (1997) studied this question.
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