December 1, 1992Arteriosclerosis and Thrombosis A Journal of Vascular Biology
LDL subclass phenotypes and triglyceride metabolism in non-insulin-dependent diabetes.
Why the study?
Is the LDL subclass phenotype B more prevalent in normolipidemic men with NIDDM compared to age-matched controls, and how does it affect triglyceride metabolism?
Population
Normolipidemic men with non-insulin-dependent diabetes mellitus and age-matched control subjects with…
Design
Case-control
Authors
Discussion
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Member takes
Implication
May flag hidden atherogenic risk in normolipidemic NIDDM; leaves open whether phenotype-guided therapy improves outcomes.
Structured PICO
Is the LDL subclass phenotype B more prevalent in normolipidemic men with NIDDM compared to age-matched controls, and how does it affect triglyceride metabolism?
P
Population
Normolipidemic men with non-insulin-dependent diabetes mellitus (NIDDM) and age-matched control subjects with similar lipid levels.
C
Comparator
Age-matched control subjects
O
Outcome
Prevalence of LDL subclass phenotype B and its association with lipid levels and triglyceride clearancesurrogate
The atherogenic LDL subclass phenotype B is significantly more common in normolipidemic men with NIDDM and is associated with impaired triglyceride clearance, independent of glycemic control.
Cite This Study
Feingold et al. (1992) studied this question.