Why the study?
Is endothelial cell activation associated with cerebral white matter lesions in patients with cerebrovascular disease?
Population
29 patients with cerebrovascular disease, including acute stroke or TIAs associated with symptomatic…
Design
Cross-sectional
Authors
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May identify high-risk symptomatic carotid stenosis patients; leaves open whether endothelial activation is causal or modifiable.
Is endothelial cell activation associated with cerebral white matter lesions in patients with cerebrovascular disease?
Endothelial cell activation markers sP-selectin and sVCAM-1 are elevated in patients with severe periventricular white matter lesions and symptomatic carotid artery stenosis, suggesting a role in small vessel disease pathogenesis.
Leeuw et al. (2002) studied this question.