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Synthesis of the heptadecapeptide melanin concentrating hormone using a novel continuous-flow solid-phase method is described. A composite polydimethylacrylamide–macroporous kieselguhr support was used permitting low pressure flow operation. Fluorenylmethoxycarbonylamino acid anhydrides were used throughout for acylation reactions. The choice of compatible side-chain protecting groups is discussed. The synthetic product showed high melanin-concentrating properties in vitro.
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Eberlé et al. (1986) studied this question.
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