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April 1, 1999Obstetrics and Gynecology

Three of four women responded to vasodilator therapy and successfully completed their pregnancies, while one non-responder died.

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Why the study?

Does treatment with pulmonary vasodilators (nifedipine and prostacyclin) improve outcomes in pregnant women with pulmonary hypertension?

Population

4 pregnant women with pulmonary hypertension

Design

Case_series

Authors

TETR Easterling

Discussion

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Overview

May support vasodilator use in select pregnant PH cases; leaves open need for prospective trials before practice change.

Structured PICO

Does treatment with pulmonary vasodilators (nifedipine and prostacyclin) improve outcomes in pregnant women with pulmonary hypertension?

P
Population
4 pregnant women with pulmonary hypertension
I
Intervention
Pulmonary vasodilators (oral nifedipine and intravenous prostacyclin) guided by right pulmonary artery catheterization and Doppler measurements of cardiac output
O
Outcome
Clinical course and pregnancy outcome (successful completion of pregnancy, maternal survival)hard clinical

Pulmonary vasodilator therapy with nifedipine and prostacyclin can lead to successful pregnancy outcomes in women with pulmonary hypertension, though early diagnosis and careful postpartum volume management are critical.

Cite This Study

TR Easterling (1999) studied this question.

synapsesocial.com/papers/6a72aac3e5469ee92be282c4https://doi.org/10.1016/s0029-7844(98)00524-9
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary Hypertension in Pregnancy1999 · 2 citations
  2. 2Pulmonary hypertension in pregnancy in the modern therapy era: A systematic review of translational management framework2025
  3. 3Management of pulmonary vasodilator therapy in three pregnancies with pulmonary arterial hypertension2017 · 16 citations
  4. 4Pulmonary Hypertension and Pregnancy2019 · 121 citations
  5. 5Pulmonary Hypertension in Pregnancy: Critical Care Management2012 · 57 citations