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April 1, 1999Obstetrics and Gynecology

Three of four women responded to vasodilator therapy and successfully completed their pregnancies, while one non-responder died.

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Why the study?

Does pulmonary vasodilator therapy improve clinical outcomes in pregnant women with pulmonary hypertension?

Population

4 pregnant women with pulmonary hypertension

Design

Case_series

Authors

TEThomas R. EasterlingDRDavid RalphBSBarbara Schmucker

Discussion

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Member takes

Overview

May support vasodilator trial in select pregnant PH patients; hypothesis-generating and should not yet change practice.

Structured PICO

Does pulmonary vasodilator therapy improve clinical outcomes in pregnant women with pulmonary hypertension?

P
Population
4 pregnant women with pulmonary hypertension
I
Intervention
Pulmonary vasodilators (oral nifedipine and intravenous prostacyclin) guided by right pulmonary artery catheterization and Doppler measurements of cardiac output
O
Outcome
Clinical course and pregnancy completionhard clinical

Pulmonary vasodilator therapy with nifedipine and prostacyclin can benefit pregnant women with pulmonary hypertension, and a favorable response before conception may predict a successful pregnancy.

Cite This Study

Easterling et al. (1999) studied this question.

synapsesocial.com/papers/6a72aac3e5469ee92be282c5https://doi.org/10.1097/00006250-199904000-00005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary hypertension in pregnancy: treatment with pulmonary vasodilators1999 · 90 citations
  2. 2Pulmonary hypertension in pregnancy in the modern therapy era: A systematic review of translational management framework2025
  3. 3Management of pulmonary vasodilator therapy in three pregnancies with pulmonary arterial hypertension2017 · 16 citations
  4. 4Pulmonary Hypertension in Pregnancy: Critical Care Management2012 · 57 citations
  5. 5Pulmonary Hypertension and Pregnancy2019 · 121 citations