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September 1, 1996AJP Cell Physiology

Cellular localization and regulation of CHIF in kidney and colon

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Population

Rats (tissue specificity studied by in situ hybridization) and Xenopus oocytes

Design

Preclinical

Authors

CCClaudia CapurroUniversity of Buenos AiresNCNathalie CoutryCentre National de la Recherche ScientifiqueJBJ. P. BonvaletCEA Paris-Saclay - Etablissement de Saclay

Discussion

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Implication

CHIF may mediate ion transport in distal nephron and colon; leaves open its role in human electrolyte disorders.

Structured PICO

P
Population
Rats (tissue specificity studied by in situ hybridization) and Xenopus oocytes
I
Intervention
Corticosteroid hormones, sodium restriction, low-potassium diet, and metabolic acidosis
O
Outcome
Tissue specificity and regulation of CHIF mRNA expressionsurrogate

CHIF is a novel protein selectively expressed in the distal nephron and distal colon, regulated by corticosteroids, electrolytes, and acid-base status, suggesting a role in ion transport.

Cite This Study

Capurro et al. (1996) studied this question.

synapsesocial.com/papers/6a72ab09fe4101aa97e0e848https://doi.org/10.1152/ajpcell.1996.271.3.c753
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Also Consider

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  4. 4Mat-8, a Novel Phospholemman-like Protein Expressed in Human Breast Tumors, Induces a Chloride Conductance in Xenopus Oocytes1995 · 150 citations
  5. 5Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry.1994 · 381 citations