Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 18, 2024Basic & Clinical Pharmacology & ToxicologyOpen Access

Long‐term taurine supplementation regulates brain mitochondrial dynamics in mice

View Full Paper
Ask AI
Bookmark
Share

Authors

HRHeresh RezaeiHWHongwei WangWTWeishun Tian

Discussion

Loading...

Member takes

Overview

Controlled animal study demonstrates improved cognitive function, reduced anxiety, and enhanced brain mitochondrial dynamics in mice, suggesting potential therapeutic utility in neurological...

Key Points

  • To evaluate the impact of long-term taurine supplementation on brain mitochondrial dynamics, biogenesis, and behavioral measures in mice.
  • Administered taurine in drinking water at concentrations of 0.25%, 0.5%, and 1% to young mice for six months.
  • Assessed memory, cognitive performance, and behavioral markers of anxiety and depression alongside mitochondrial indices and the expression of regulatory genes (Akt, CREB, NRF1, TFAM, PGC-1α, Mfn1, Mfn2, UCP2, PINK1, OPA1, Drp1, and Fis1).
  • Taurine supplementation significantly enhanced memory performance and attenuated anxiety- and depression-like behaviors relative to controls.
  • Taurine significantly increased mitochondrial biogenesis and dynamic markers while improving overall mitochondrial indices.
  • Mitochondrial dynamic biomarker changes showed no significant difference across the three evaluated taurine concentrations (0.25%, 0.5%, and 1%).

Cite This Study

Rezaei et al. (2024) studied this question.

synapsesocial.com/papers/6a72ae0bfe4101aa97e0e90ahttps://doi.org/10.1111/bcpt.14101
View Full Paper
Ask AI
Bookmark
Share