What question did this study set out to answer?

To examine the acute metabolic effects of acylated ghrelin, unacylated ghrelin, and their combination on circulating glucose, insulin, and insulin sensitivity in humans.

October 1, 2004The Journal of Clinical Endocrinology & Metabolism

Administration of Acylated Ghrelin Reduces Insulin Sensitivity, Whereas the Combination of Acylated Plus Unacylated Ghrelin Strongly Improves Insulin Sensitivity

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Authors

CGCarlotta GaunaUniversity of Turin FMF. M. MeylerErasmus MC JJJ. A. M. J. L. JanssenErasmus MC

Discussion

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Implication

Clinical trial demonstrates that combining acylated and unacylated ghrelin improves insulin sensitivity in growth hormone-deficient adults, suggesting therapeutic utility for metabolic disorders.

Key Points

To examine the acute metabolic effects of acylated ghrelin, unacylated ghrelin, and their combination on circulating glucose, insulin, and insulin sensitivity in humans.
Administered acylated ghrelin, unacylated ghrelin, the combination, or placebo acutely to eight adult-onset growth hormone-deficient patients (N=8).
Monitored glucose, insulin, and free fatty acid concentrations before and after a meal over a 6-hour period, with and without circulating growth hormone.
Acylated ghrelin induced a rapid elevation in glucose and insulin levels and reduced insulin sensitivity for up to 6 hours after administration.
Coadministration of unacylated ghrelin prevented acylated ghrelin-induced spikes in glucose and insulin and significantly improved insulin sensitivity compared with placebo for at least 6 hours.

Cite This Study

Gauna et al. (2004) studied this question.

synapsesocial.com/papers/6a72aeda5d37378ac1df5af9 https://doi.org/10.1210/jc.2004-0363

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Implication

Clinical trial demonstrates that combining acylated and unacylated ghrelin improves insulin sensitivity in growth hormone-deficient adults, suggesting therapeutic utility for metabolic disorders.

Administration of Acylated Ghrelin Reduces Insulin Sensitivity, Whereas the Combination of Acylated Plus Unacylated Ghrelin Strongly Improves Insulin Sensitivity

Discussion

Member takes

Implication

Key Points

Cite This Study

Administration of Acylated Ghrelin Reduces Insulin Sensitivity, Whereas the Combination of Acylated Plus Unacylated Ghrelin Strongly Improves Insulin Sensitivity

Discussion

Member takes

Implication

Key Points

Cite This Study

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